【摘 要】
：
目的:采用单纯高脂喂养以及高脂喂养联合股动脉球囊损伤两种造模方法建立新西兰兔动脉粥样硬化模型,并利用二维超声和超声造影方法比较两种造模方法的优劣.方法:1、分别用单纯高脂喂养、高脂喂养联合股动脉球囊损伤方法建立新西兰兔动脉硬化模型.每两周一次二维超声观察括管壁毛糙、内中膜增生、粥样斑点、斑块等,并测量内中膜厚度和腹主动脉管径.2、造模的不同阶段行声诺维超声造影,每只观察90秒,利用Logic E9
【机 构】
：
西安交通大学第一附属医院超声诊断科 西安交通大学第一附属医院心脏内科
【出 处】
：
中华医学会第十五次全国超声医学学术会议
论文部分内容阅读
目的:采用单纯高脂喂养以及高脂喂养联合股动脉球囊损伤两种造模方法建立新西兰兔动脉粥样硬化模型,并利用二维超声和超声造影方法比较两种造模方法的优劣.方法:1、分别用单纯高脂喂养、高脂喂养联合股动脉球囊损伤方法建立新西兰兔动脉硬化模型.每两周一次二维超声观察括管壁毛糙、内中膜增生、粥样斑点、斑块等,并测量内中膜厚度和腹主动脉管径.2、造模的不同阶段行声诺维超声造影,每只观察90秒,利用Logic E9超声造影分析软件进行分析,获得ACU比值(斑块处:管腔中央).结果:1、26只新西兰兔随机分为两组.3只分别死于腹泻、麻醉剂过量和术中大出血,余23只实验兔实验结束处死,病理证实均形成明显的动脉粥样硬化病变,成功率88.5％.
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