LIMITED ROLE OF GENOTYPING FOR THE PREDICTION OF CLOPIDOGREL ANTIPLATELET EFFICACY IN CHINESE PATIEN

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户：blackfairy

【摘要】

：

【作者】

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Yin Tong Ying Jin Lanning Zhang Xiaoqi Li Caiyi Lu

【机构】

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Institute of Geriatric Cardiology,General Hospital of Chinese People's Liberation Army,Beijing 1008

【出处】

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第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int

【发表日期】

：

2013年2期

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Objectives Cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogel absorption and bioactivation.Genotypes in these genes have been associated with the variability of responsiveness to clopidogrel, however their contribution to clopidogrel antiplatelet efficacy in clinical practice is controversy.

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LIMITED ROLE OF GENOTYPING FOR THE PREDICTION OF CLOPIDOGREL ANTIPLATELET EFFICACY IN CHINESE PATIEN

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