【摘 要】
：
The objective of this study was to evaluate the cardiac toxicity of the carboplatin, a second generation platinumcontaining anti-cancer drug, and to test the hypothesis whether low dosage ofpravastati
【机 构】
：
Department of Physiology Taipei Medical University Taiwan
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
The objective of this study was to evaluate the cardiac toxicity of the carboplatin, a second generation platinumcontaining anti-cancer drug, and to test the hypothesis whether low dosage ofpravastatin can reduce carboplatininduced cardiomyopathy.In the present study, carboplatin (100mg/kg) infused to mice would result in a reduction of survival rate and abnormal cardiac histology, concomitant with an increase of cardiac apoptosis via TUNEL and DNA fragmentation assay.In addition, carboplatin treated (200 μM for 48 hours) cultured rat cardiomyocytes showed increased cardiomyocyte apoptosis with increased caspase-3,-9, and cytochrome C, but decreased BCL-XL protein expression, in which the process could be inhibited by the reactive oxygen species (ROS) scavenger, n-acetylcysteine.
其他文献
Gastric carcinogenesis associated with Helicobacterpylori (H.pylori) infection might develop firom the consequence of accumulated imbalance between apoptosis and cell proliferation since a disturbance
Introduction: Esophageal cancers occur at very high frequency in certain parts of China, Iran, South Africa, Uruguay, France, and Italy and in some regions of India.The highest incidence of this cance
Genetic variations are frequent in humans, and the challenge of cancer biology is to discover which polymorphisms influence cancer risk.Single nucleotide polymorphism (SNP) is the largest type of inhe
The taxanes are amongst the most effective cytotoxics used in the management of ovarian and breast cancer.Despite their proven efficacy, taxane resistance is associated with significant patient morbid
The production of therapeutic monoclonal antibodies is at the forefront of the bio-pharmaceutical industry.The protein therapeutic market was valued in excess of $57 billion in 2006, with monoclonal a
Prostate cancer (CaP) is the second most common cancer in men.In US, between 5% and 12.5% of men from age 60 to 79 develop CaP.In China, CaP incidence was low but has been rising in recent years.Curre
Objectives: Prostate cancer is the second leading cause of cancer mortality among men in the U.S.To the authorsknowledge, there was no improved, second-line therapy for metastatic hormone refractory p
The present study aimed at investigating the enhanced effects and genes expression in the cell cycle distribution and apoptosis ofU937 cells, a human pre-monocytic leukemia cell line lacking functiona
Short palate, lung and nasal epithelium clone 1 (SPLUNC1) gene coded a secreted protein found at the surface of nasopharyngeal epithelium, which may be an important risk factor for nasopharyngeal carc
Background: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes.Cancer cells may occasionally divide into three or more directions, known