【摘 要】
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Objective:Primary hyperuricaemia (HUA),an excess of uric acid in the blood,remains a major public health problem.In addition to the morbidity that is attributable to gout,HUA is associated with the me
【机 构】
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Department of Clinical Laboratory,Peking Union Medical College Hospital
【出 处】
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中华医学会第八次全国中青年检验医学学术会议
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Objective:Primary hyperuricaemia (HUA),an excess of uric acid in the blood,remains a major public health problem.In addition to the morbidity that is attributable to gout,HUA is associated with the metabolic syndrome,hypertension,and cardiovascular disease.The Aim of this study was to assess the genetic associations of Apolipoprotein E (ApoE) polymorphisms and primary hyperuricemia in a Chinese population.Methods:A total of 770 subjects (356 cases and 414 control subjects) were recruited from Ningxia Hui Autonomous Region,China.Physical examination was performed and fasting blood was collected for biochemistry testing including serum lipid,creatinine,and uric acid et al.The multi-ARMS PCR was applied to determine ApoE genotypes,and then the distribution of ApoE genotypes and alleles frequencies in controls and cases were analyzed.
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