【摘 要】
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The last decade has witnessed significant advances in our understanding of the physiological roles of orexin (also known as hypocretin), a novel neuropeptid
【机 构】
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Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechno
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
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The last decade has witnessed significant advances in our understanding of the physiological roles of orexin (also known as hypocretin), a novel neuropeptide first identified in 1998.As a neurotransmitter system originating uniquely from the lateral hypothalamus/perifornical area but projecting extensively to almost the whole brain, the central orexinergic system has been implicated in many basic nonsomatie functions, including the sleep/wake states, feeding, and reward processes.However, whether the central orexinergic system has a role in somatic motor control remains enigmatic.Intriguingly, orexin deficiency in humans, dogs, and rodents results in cataplexy, a motor deficit characterized by sudden loss of muscle tone, highlighting the possibility of a modulatory role for orexin in motor control.
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