双酚A(BPA)暴露对海水青鳉(Oryzias melastigma)心血管系统早期生长发育的毒性作用机制研究

来源 :第五届全国海洋生态研讨会暨中国生态学学会海洋生态专业委员会2015年学术年会 | 被引量 : 0次 | 上传用户:zxh87
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  双酚A (BPA)是一类在海洋环境中广泛分布的内分泌干扰物质,但其对海洋生物心血管系统的毒性作用机制尚缺乏研究.本研究利用海水青鳉(Oryzias melastigma)胚胎为模型,探讨接近于环境浓度的BPA(200 μg/L)通过水相暴露,对海水青鳉心血管系统早期生长发育的毒性作用机制.研究发现,海水青鳉胚胎对BPA的富集量以孵化后第6天(6 dpf)为分界点呈先升后降的趋势,吸收速率为0.21×10-3 L/g/d;同时,其主要代谢产物BPA-葡糖苷酸(BPAG)在胚胎中的含量呈逐步上升趋势,表明海水青鳉在早期生长发育阶段即可有效代谢和转化BPA,代谢速率为0.38±0.10/d,与其它类似性质的污染物相比,BPA更容易被代谢.
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