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Objective:Using the ACR Ped-30,50,70 to assess the clinical efficacy of tumor necrosis factor antagonist in refractory systemic juvenile idiopathic arthritis (So-JIA).Methods:Evaluate the 30 refractory SO-JIA patients that achieved TNF antagonists using ACR Ped-30,50,70.The evaluation will carry out after treatment of 1 month,3 months and 6 months.Several indicators will be evulate,insist:(1)the dosage of the hormone.(2)the body temperature (3)count of active inflammatory joint (4)blood sedimentation (ESR) or c-reactive protein (CRP).