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<正>SHENMAI injection(SMI) is a kind of herbal injection widely used in China derived from SHENMAI formula.Ginsenosides are the major components in SMI.In order to monitor the exposure level of SMI during long-term treatment,a 6-month toxicokinetic experiment was performed.24 beagle dogs were dived into four groups:Control Group(0.9%NaCl solution;n = 6),Low-dosage Group(2 g/kg;n = 6),Medium-dosage Group(6 g/kg;n = 6) and High-dosage Group(20 g/kg;n = 6).Vehicle and SMI were i.v.drip injected everyday for 180 continuous days