Objective:To explore the influence of YYDB on the phagocytosis of macrophage caused by chicken erythrocytes in peritoneal of mouse and evaluate the effect of YYDB on the nonspecific immune function.Methods:There were five groups named by the blank control group,Yiganfuzheng Jiaonang group(the positive control group),the high-,medium-and low-dose group.As for five groups,all drugs were administered respectively by intragastric (i.g.) for 7 consecutive days.Mouse in each group were injected 0.5ml soluble starch broth(6%) on the Sth day and Iml chicken erythrocytes (1%) on the 7th day after intraperitoneal administration.Evaluate the effect of YYDB on the phagocytosis of macrophage in peritoneal of mouse according to macrophage phagocytic index and phagocytic rate.Results:Compared with the blank control group,phagocytic rate in the three groups of YYDB increased,while macrophage phagocytic index were an increase in high-and medium group which both of them revealed statistically significant (P<0.05).Conclusion:YYDB is good to enhance the phagocytosis of macrophage in peritoneal of mouse.