Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

来源 :The 9th Asian Biophysics Association Symposium (ABA2015)(第九届 | 被引量 : 0次 | 上传用户：zzh787

【摘要】

：

Clustered regularly interspaced short palindromic repeats (CRISPR) together with CRISPR-associated (Cas) proteins form the CRISPR/Cas system to defend against f

【作者】

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Hongtu Zhao Gang Sheng Jiuyu Wang Min Wang Gabor Bunkoczi Weimin Gong Zhiyi Wei Yanli Wang

【机构】

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LaboratoryofRNABiology,InstituteofBiophysics,ChineseAcademyofSciences,Beijing100101,China;University

【出处】

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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届

【发表日期】

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2015年5期

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Clustered regularly interspaced short palindromic repeats (CRISPR) together with CRISPR-associated (Cas) proteins form the CRISPR/Cas system to defend against foreign nucleic acids of bacterial and archaeal origin1-9.In the I-E subtype CRISPR/Cas system, eleven subunits from five Cas proteins (CasA1B2C6D1E1) assemble along a CRISPR RNA (crRNA) to form the Cascade complex10-13.

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Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

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