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Objectives To evaluate the cardioprotective effect of atorvastatin (Ator) via modulation of mitochondrial permeability transition pore (mPTP) through mitochondrial ATP-sensitive potassium channels (mitoKATP channels).Methods Sprague-Dawley rat hearts were Langendorff-perfused with Krebs-Henseleit (K-H) buffer and subjected to 30 min global ischaemia followed by 120 min of reperfusion.