Traditional Chinese Medicine (TCM), which used to be the leading power in the medical science of the world,nowadays, is tending to be neglected by the public.TCM is facing critical crisis and great challenges.This paper pointed out the two major reasons why TCM was fall behind the modern society: 1 TCM had missed the opportunity to merge with modern science and technology.2.The development guidelines for TCM were still as old as hundreds years ago and were out of time.Based on these analyses,the author raised four approaches to resolve the current problems of TCM.1.TCM should keep pace with modern technology development:①Herb drugs are being evolved with environment changing and is no longer same as what they were centuries before.②The cause of diseases also has been changing.③The formulations and therapeutic regimen should change with times;2.TCM innovation and research should based on modern science and technology:①TCM syndrome differentiation should be based on biological essence even match with genetic targets.②Pathogeny and treatments of diseases should be deepen into molecular level;3.The research of TCM prescription should combine with modern science and technology;4.In the development of TCM, researchers should pay enough attention to safety evaluation and drug quality by using modern scientific assessment methods.In the end, the author concluded that TCM and modern western medicine would go together to the physical nature of human being.