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  5. Doxorubicin-loaded polymeric micelles based on bioactive polypeptides: Suppress invasion of melanoma

Doxorubicin-loaded polymeric micelles based on bioactive polypeptides: Suppress invasion of melanoma

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：yyjay1315
【摘 要】
：
Few studies concerning the conformational effect of polypeptides on drug delivery have been reported,although conformation of different polypeptides has been well-explored in the past few years.Here,w
【作 者】
：
Oi-Ming Wang Zhonggao Gao Shan Liu Bo Fan Lin Kang Wei Huang Mingji Jin 
【机 构】
：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia M
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
poly(L-glutamic acid) Tat peptides doxorubicin cell invasion cardiotoxicity 
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　　Few studies concerning the conformational effect of polypeptides on drug delivery have been reported,although conformation of different polypeptides has been well-explored in the past few years.Here,we report that the conformational change of poly(L-glutamic acid) regulates anti-melanoma activity of doxorubicin(DOX)-loaded hybrid polymeric micelles (D-h) [1].We synthesized poly(Lglutamic acid)5.6k-b-poly(D,L-lactic acid)1.8k [PGA5.6k-b-PLA1.8k] and constructed D-h with PGA5.6k-bPLA1.8k,PEG2k-b-DSPE and Tat peptides (Tatp) modified PEG3.5k-b-DSPE (Tatp-PEG3.sk-b-DSPE).
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