A transdermal drug delivery system was prepared by high methoxyl pectin(HMP)or low methoxyl pectin(LMP)coated vitamin C liposomes.HMP coated vitamin C liposomes(HMP-L)and LMP coated vitamin C liposomes(LMP-L)exhibited an increase in average diameter(from 66.9 nm to 117.3 nm and 129.6 nm,respectively),a decrease in zeta potential(from -2.3 mV to -23.9 mV and -35.5 mV,respectively),and a similar entrapment efficiency(48.3–50.1%).Morphology and FTIR analysis confirmed that pectin was successfully coated on the surface of vitamin C liposomes mainly through the hydrogen bonding interactions.Besides,HMP-L and LMP-L exhibited an obvious improvement in storage stability,with lower aggregation,oxidation of lipid and leakage ratio of vitamin C from liposomes,and LMP-L showed better physicochemical stability than HMP-L.Moreover,skin permeation of vitamin C was improved 1.7-fold for HMP-L and 2.1-fold for LMP-L after 24 h,respectively,compared with vitamin C nanoliposomes.Therefore,this study suggested that pectin coated liposomes,especially the LMP-L,could be a promising transdermal drug delivery system with better storage stability and skin permeation.