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This study aimed to characterize the plasma protein profile and common interaction network of patients with cervical squamous cell carcinoma (CSCC) using a proteomics approach and to identify protein markers for the early prognosis and diagnosis of this cancer type.Plasma samples from 26 Uyghur women with CSCC in Xinjiang and 22 healthy donors were depleted of high-abundance proteins and analyzed using 2D-HPLC to characterize the proteome profile common to CSCC.