脑瘫的病理生理中枢神经系统损伤后,失去了对低级中枢的抑制,使低级中枢的控制作用释放出来,以致肌张力异常.患肢在进行任何活动时,都不能随意的、有选择性的控制,从而表现出异常的原始的姿势反射.这种原始的姿势反射,使一些不同部位的肌肉张力发生特定的变化,造成异常的运动模式.异常模式必造成肌能的动力性平衡失调,也改变了人体的生物力平衡.长期的异常造成肌腱的挛缩和关节和畸形.
The efficacy and safety of new drugs must be evaluated in animal models before drug candidates can be investigated in humans.In the majority of cases the animals will be a rodent, such as mice or rats
Aberrant tyrosine phosphorylation has been linked to the etiology of many human diseases including cancer, diabetes/obesity, neurodegenerative and autoimmune disorders.Notable success has been achieve
Urocortin 2 (Ucn2), a peptide of the corticotropin-releasing factor (CRF) family, binds with high affinity to type 2 CRF receptors (CRFR2) on cardiomyocytes and confers protection against ischemia/rep
Autoimmune diabetes or type 1 diabetes (T1D) is resulted from the interaction of susceptible genes and environmental factors.DNA methylation acts as a bridge to link susceptible genes and environmenta
The ability of adipose tissue to dispose of circulating fatty acids (FAs) by oxidation or storage as triglyceride (TAG) has important metabolic and clinical implications, by preventing the accumulatio
Background There is currently a challenge for the treatment of diabetic peripheral neuropathy (DPN) and the pathogenesis of DPN is largely unknown.Autophagy is an important physiological process and a
To investigate whether MyD88 in the gut epithelial brush border plays a role in obesity and metabolic syndrome, we studied a transgenic mouse line expressing MyD88 only in villus (VillinMyD88+/+MyD88-
OBJECTIVE The HLA-DR-DQ genes are well established as being associated with risk for type 1A diabetes(T1A).However, the HLA class Ⅱ genetics of LADA are still not compeletely clear.We have therefore i
Objetive To investigate the relationship between serum dipeptidyl peptidase-4 (sDPP-4) and body fat content and distribution in type 2 diabetes (T2DM).Methods A total of 40 T2DM patients treated in Th