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目的 AccumulatingevidenceshavebeenidentifiedthatCSCsplayapivotalroleintumorregeneration,metastasisanddrugresistanceinlungcancer.Toll-likereceptor9(TLR9),whenactivatedbyitsligandsCpGoligodinucleotides(CpG-ODN),cantriggerIKK/NF-kB,MAPK/AP-1andPI3K/Aktsignalpathways,andfinallycontributetothegrowthandmetastasisoflungcancercells.