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5. A Novel Nitroreductase-enhanced MRI Contrast Agent and its Potential Application in Bacterial Imagin

A Novel Nitroreductase-enhanced MRI Contrast Agent and its Potential Application in Bacterial Imagin

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：xiaoyu19771121

【摘 要】

：

Nitroreductases(NTRs)are present in a wide range of bacterial genera and,to a lesser extent,in eukaryotes hypoxic tumour cells and tumorous tissues,which makes it an appropriate biomarker for an imagi

【作 者】

：

Yun Liu Leilei Zhang Marc Nazare Qingqiang Yao Hai-Yu Hu 

【机 构】

：

Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences,Bei

【出 处】

：

中国化学会第十届全国化学生物学学术会议

【发表日期】

：

2017年10期

【关键词】

：

Nitroreductase MRI contrast agent Smart imaging probes Bacterial Imaging 

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　　Nitroreductases(NTRs)are present in a wide range of bacterial genera and,to a lesser extent,in eukaryotes hypoxic tumour cells and tumorous tissues,which makes it an appropriate biomarker for an imaging target to detect the hypoxic status of cancer cells and potential bacterial infections.

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