【摘 要】
：
DNA double strand break is one of the most detrimental DNA damages, which must be repaired for the maintenance of genomic stability.Damage recognition by the Mre11-Rad50-Nbs1 complex is the earliest e
【机 构】
：
Department of Life Science,Pohang University of Science and Technology,Korea
【出 处】
：
The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
DNA double strand break is one of the most detrimental DNA damages, which must be repaired for the maintenance of genomic stability.Damage recognition by the Mre11-Rad50-Nbs1 complex is the earliest essential event for DSB repair process.In the talk, I will present a new model by which the complex recognizes DNA damage and resect to initiate the homologous recombination repair using integrative approaches.
其他文献
Focusing on the roles of progressive telomere deprotection in cells approaching replicative senescence, we discovered that critically short telomeres signal differently than intrachromosomal DNA break
DSBs induced in heterochromatic regions are repaired with slow kinetics by a process requiring ATM, Artemis and ATM signaling factors.This process represents homologous recombination in G2, but its na
The expression level of SLFN11 is causally associated with the activity of DNA-damaging agents in human cancer cells.However, little is known about the mechanism by which this occurs.Here we show that
Ataxia Telangiectasia (AT) is a rare monogenic disorder, inherited as autosomal recessive, characterized by progressive cerebellar ataxia associated with loss of Purkinje cells, oculocutaneous telangi
Ataxia-Telangiectasia (A-T) is the most prominent among the inherited neuropathological disorders caused by defects in the DNA damage response pathway.Albeit neurodegeneration in A-T has initially bee
Introduction: Ataxia Telangiectasia (A-T) is a rare genetic disorder with symptoms including ataxia and involuntary movements, higher risk of infections, and high risk of cancer [1].There is currently
The loss of Ataxia Telangiectasia Mutated (ATM) protein function is a frequent event in the pathogenesis of sporadic haematopoietic malignancies such as Chronic Lymphocytic Leukaemia (CLL), T-Prolymph
Fanconi anemia (FA) is a rare genetic disease characterized by genome instability,cancer predisposition, bone marrow failure and various developmental abnormalities.Here we report two unrelated Japane
Nijmegen breakage syndrome (NBS) as well as Ataxia Telangiectasia (A-T) is a radiation-hypersensitive genetic disorder, showing chromosomal instability, radioresistant DNA synthesis, and predispositio
Structure-specific nucleases play crucial roles in DNA replication and DNA repair.The mechanisms of their regulation are not fully understood.Recently we reported a fission yeast protein, Pxd1, that r