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  5. Aquaporin-1 dependent proximal tubular cells migration mediates reno-protective effect of acetazolam

Aquaporin-1 dependent proximal tubular cells migration mediates reno-protective effect of acetazolam

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：jonelove0000
【摘 要】
：
Aim: The study is to investigate whether diuretic acetazolamide (AZA) protects against renal ischemia-reperfusion (I/R) injury, and its possible link with water channel aquaporin-1 (AQP1).Methods: In
【作 者】
：
Yu AN Xue-jun LI 
【机 构】
：
Department of Pharmacology, School of Basic Medical Sciences,Peking University, Beijing 100191, Chin
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
Aquaporin-1 (AQP1) ischemia-reperfusion acute kidney injury acetazolamide migrat 
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Aim: The study is to investigate whether diuretic acetazolamide (AZA) protects against renal ischemia-reperfusion (I/R) injury, and its possible link with water channel aquaporin-1 (AQP1).Methods: In vivo study was conducted using AQP1 wild-type (AQP1+/+) and knock-out (AQP1-/-) mice, randomly divided into three groups: sham, I/R and AZA treatment group.
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