【摘 要】
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Patients with neuroblastoma due to N-Myc oncogene-amplification die of tumour metastasis.However, little is known about how N-Myc induces cell migration, invasion and metastasis.The histone demethylas
【机 构】
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Children's Cancer Institute Australia for Medical Research Australia
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Patients with neuroblastoma due to N-Myc oncogene-amplification die of tumour metastasis.However, little is known about how N-Myc induces cell migration, invasion and metastasis.The histone demethylase JMJD 1A activates target gene transcription by demethylating lysine 9 residues of histone H3 (H3K9).Here we demonstrated that N-Myc up-regulated the expression of JMJD 1A in N-Myc oncogene-amplified human neuroblastoma cells by directly binding to JMJD 1A gene promoter.
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