Use of respiratory “head out” plethysmographs for evaluation of pulmonary function in rats

来源 :2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛 | 被引量 : 0次 | 上传用户:shenzhixian
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  To evaluate the use of respiratory "head out" plethysmographys for use as a respiratory function assessment tool in rats as part of the respiratory system assessment required under the ICH S7A guideline.Morphine (20 mg·kg-1 iv) and Theophylline (10 mg·kg-1 iv) were selected for use as reference compounds in this study.Male Sprague Dawley rats, approximately 7-8 weeks of age and in the weight range 246-303 g were selected as the test system.
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