Network and Pathway Based Analyses of Genes Associated with Parkinson's Disease

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户:liuyongqiang615
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Parkinsons disease (PD) is a major neurodegenerative disease influenced by both genetic and environmental factors.Although previous studies have provided insights into the significant impact of genetic factors on this disease,the molecular mechanism underlying PD remains largely unclear.Under such situation,a comprehensive analysis focusing on the biological function and interactions of PD-related genes will provide us valuable information to understand the pathogenesis of PD.
其他文献
Promoters,DNA regulatory elements,are in charge of the transcription of genes.With the appearance of a large number of genome sequences,it is urgent to use bioinformatics method combining with known e
Diagnosed and detected biomarkers (DDMarker),is a biomarker evaluation system which exams,whether the diseases are caused by a certain computing expression pattern.It enables researchers to identify g
The initiation of replication is an extremely important process in DNA life cycle.Given an uncharacterized DNA sequence,can we identify where its origin of replication (ORI) is located? It is no doubt
Background: Essential genes are indispensable for the survival of organisms.Up to now,those important elements have been screened in more than forty bacteria by wet-lab methods.It provides a chance to
k-mer usage in genome sequences is not random,the nonrandom evolution and its cause are worthy of special attention.After analyzing 8-mer frequency spectrum in human,it is found that arisen frequency
Hepatocellular carcinoma (HCC) is one of the common malignant tumors.Accurate diagnosing of HCC is of great importance.k-NFN (k-Nearest and Farthest Neighbors)[1]is an ensemble classifying method whic
Schizophrenia and bipolar disorder are complex mental disorders,with risks contributed by multiple genes.Recently,genome-wide systemic approaches have been used to reveal the associations of hundreds
Bipolar disorder is a common psychiatric disorder with high heritability.Integrative gene expression data and genetic data would facilitate disease related gene dysfunction and related biological func
Both neurodegenerative and psychiatric disorder are common and severe CNS diseases with symptom similarity and comorbidity;however,the underlying biological processes across these disorders remain lar
Production of maternal haploids via intra-specific genotypes as the haploid inducer is routine and highly efficient in maize.However,the underlying mechanism of haploid induction (HI) is unclear.Triph