Cold stimuli evoke more rapid transient pain sensations in human teeth than hot stimuli.However, the underlying mechanism remains unknown.It has been reported that hot stimuli cause an inward flow (toward the tooth pulp chamber) of the dentinal fluid in dentinal microtubules while cold stimuli cause flow in a reverse direction.This study attempts to quantify tooth pain sensation by coupling a computational fluid dynamics (CFD) model, which describes the fluid mechanics in dentinal microtubules, with a modified Hodgkin-Huxley (H-H) model, which describes the neural discharge behavior.