【摘 要】
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Background& Objective: Tumor-associated macrophages (TAM) are induced by many cytokines, such as IL-4, IL-10,IL-13, and are considered to be of the M2 phenotype, which provides an immunosuppressive mi
【机 构】
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Department of Immunology, Chinese Academy of Medical Sciences
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Background& Objective: Tumor-associated macrophages (TAM) are induced by many cytokines, such as IL-4, IL-10,IL-13, and are considered to be of the M2 phenotype, which provides an immunosuppressive microenvironment for tumor growth.However, biomechanist suggest that cells in the tumor microenvironment are affected not only by chemical signals but also mechanical factors, of which the stiffness of tissues is a major determinant.Compared with normal tissues, including the peri-tumor tissues, tumor tissues are more rigid.Heretofore, the influence, on the differentiation and function of macrophages, of the differences in such physical aspect between tumor tissues and otherwise, has not been elucidated.To observe the impact of the stiffness of polyacrylamide gel on the differentiation and function of macrophage, and illuminate the mechanism of tissue stiffness promoting the tumor growth through TAM.
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