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5. Synthesis of novel 10-hydroxycamptothecin derivatives utilizing Topotecan as ortho-Quinone Methide P

Synthesis of novel 10-hydroxycamptothecin derivatives utilizing Topotecan as ortho-Quinone Methide P

来源 :全国药物化学学术会议暨第四届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：lvchao222

【摘 要】

：

Camptothecin(CPT)is a pentacyclic alkaloid that was isolated by Wall and Wani from Camptotheca acuminate in 1966,and show potent inhibitory activity against a broad spectrum of tumors.

【作 者】

：

Han-yi Tan Jia-jun Li Guang-rong Meng Qian Zhang 

【机 构】

：

Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203

【出 处】

：

全国药物化学学术会议暨第四届中英药物化学学术会议

【发表日期】

：

2013年11期

【关键词】

：

Camptothecin Topotecan Ortho-quinone methide intermediate Antiproliferation acti 

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　　Camptothecin(CPT)is a pentacyclic alkaloid that was isolated by Wall and Wani from Camptotheca acuminate in 1966,and show potent inhibitory activity against a broad spectrum of tumors.

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