肿瘤细胞中转录因子WSTF在Notch信号调控H4K16乙酰化通路间的作用

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：doudou2008

【摘要】

：

目的:肿瘤细胞常发生Notch信号和表观遗传修饰的异常.阐明Notch信号与表观遗传修饰之间的调控机制将有益于个体医疗.我们的前期研究发现,在肝癌和乳腺癌细胞中Notch信号的激活可导致组蛋白H4第16位赖氨酸的乙酰化(H4K 16ac)水平下调.此过程由双微体蛋白(murine double minute,MDM2)及其下游的组蛋白乙酰化酶MOF(male on the first)参与.然而,

【作者】

：

李玉辉刘岩李玉凤刘艳坤张景华胡万宁

【机构】

：

唐山市人民医院、肿瘤医院河北联合大学

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

Notch 组蛋白乙酰化 WSTF MOF MDM2

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Hypoxia and Escherichia coli LPS-induced periodontal resident cells PAMP expressions

Background: The recognition of anaerobic periodontopathogens related molecular patterns (PAMP) by Toll-like (TL) and/or NOD-like receptors (NLRs) of human gum lining cells could lead to local chronic

会议

Hantaan A9 virus nucleocapsid protein and glycoprotein regulate interferon pathway in a dose-depend

Background: Hantaviruses can cause serious diseases in humans called hemorrhagic fever with renal syndrome ,HFRS and hantavirus pulmonary syndrome, HPS.Hantaviruses are zoonotic,enveloped and three-se

会议

Hantaan virusnucleocapsid proteinglycoproteininterferon pathwayinnate immune

Downregulation of Runx3 closely related to the decreased Th1-associated factors in patients with gas

Background: Runt-related transcription factor 3 (Runx3) is a tumor suppressor gene and plays an important role in immune regulation, whose reduced expression may play an important role in the developm

会议

Runx3T-betIFN-γImmune regulationGastric carcinoma

新型免疫调节分子TIPE2参与HCV致癌过程及其分子机制

背景:新型免疫调控因子TIPE2 [Tumor necrosis factor (TNF)-αinduced protein 8-like 2(TNFAIP8L2)]是一种在炎症反应及免疫自稳过程中不可或缺的负性调控因子.在人体内,TIPE2不仅在免疫细胞中表达,而且还广泛表达于非免疫细胞,这就提示TIPE2可能在人体非免疫组织及细胞也具有一定的调节功能.目的:通过对TIPE2是否参与HCV致癌过

会议

HCVHCCTIPE2DNA损伤/修复

Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency: a Single Center E

Rationale: Severe combined immunodeficiency (SCID), a rare primary immunodeficiency dieases (PID), is poorly characterized in mainland China.We retrospectively reviewed patients with SCID refered to o

会议

Regulation of NK cells by hepatoma cell line HepG2.2.15 compared with parental HepG2 demonstrates a

Backgroud: Hepatitis B virus (HBV) is one of the major causes of liver cirrhosis and hepatocellular carcinoma, and being a world-wide health concern, extensive fundamental and clinical researches have

会议

natural killer cellhepatitis B virusCD69interferon-γ

PMA实时作用下L-selectin/LFA-1与其配体的二维相互作用测量

L-选择素与β2整合素为白细胞膜表面表达的粘附分子.二者与血管内皮细胞表面表达的配体相互作用,在炎症级联反应中起重要作用:L-选择素-配体相互作用介导初期流动相白细胞在血管内皮细胞上的捕获,β2整合素-配体相互作用主要介导白细胞后续在血管内皮细胞上的滚动与稳定粘附.两者在功能时序上紧密相连,然而二者之间是否及如何实现功能上的接力尚不清楚[1].

会议

CD4+Foxp3+ Tregs protect against innate immune cell-mediated fulminant hepatitis in a C57BL/6 mice m

Background and Aims: Foxp3+ Tregs are important for maintaining homeostasis by controlling excessive immune responses that cause serious tissue damage;yet, relatively little is known about the impact

会议

Treginnate immuneliver injuryTGF-β

LDL和HDL作为调理素增强单核细胞对A群链球菌的吞噬效率

研究背景:我们以往的研究证实,低密度脂蛋白(LDL)可以与多个血清型的A群链球菌(GAS)表面的1型胶原样结合蛋白(Streptococcal collagen-like protein 1,Scl1)结合.我们前期的研究也证实高密度脂蛋白(HDL)可以与M41型GAS表面的Scl1特异性结合.在此基础上,我们提出了LDL和HDL可能作为调理素促进单核细胞对GAS的吞噬的假说.目的:证明LDL和H

会议

低密度脂蛋白高密度脂蛋白调理素A群链球菌单核细胞

Rotavirus infection alters the expression of cellular microRNA species that mediates antiviral defen

Rotaviruses (RVs) are the leading cause of severe diarrhea among infants and young children worldwide.Preventive and therapeutic strategies are urgently required to fight this pathogen.The human genom

会议

RotavirusesdiarrheamiR-490miR-512-5preplication

肿瘤细胞中转录因子WSTF在Notch信号调控H4K16乙酰化通路间的作用

与本文相关的学术论文