Somatic CRISPR/Cas9-induced mutations reveal roles of embryonically essential dynein chains in C.ele

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户:ljyxq13571302523
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Cell migration is an essential event of metazoan development.Understanding the dynamic behavior of cell migration in living animals is important but also challenging since the complicated extracellular environment and many key regulators are required for the embryonic developmental processes so their mutations often cause embryonic lethality.
其他文献
  Down-regulation of hSSB 1, a single-stranded DNA-binding protein, causes increased radiosensitivity, defective checkpoint activation and genomic instability
会议
  CLASPIN is an essential mediator in the DNA replication checkpoint, responsible for ATR (ataxia telangiectasia and Rad3-related protein)-dependent activatio
会议
  The assembly and maintenance of flagella and cilia depends on Intraflagellar transport (IFT).Mutations in the gene encoding IFT43, a subunit of the IFT comp
会议
  Poly ADP-ribosylation is a unique posttranslational modification participating in many biological processes such as DNA damage response.
会议
  Cilia assembly and maintenance are powered by the kinesin-2-driven anterograde intraflagellar transport (IFT) and the dynein complex mediated retrograde IFT
会议
  LiCl induces flagellar or ciliary elongation in Chlamydomonas as well as in mammalian cells.The molecular target of LiCl is widely regarded as glycogen synt
会议
  Motile cilia and eukaryotic flagella typically contain a'9+2'arrangement of axonemal microtubules attached with accessory structures, such as dynein arms an
会议
  Intraflagellar transport (IFT), a bidirectional transport system between the ciliary base and tip, delivers ciliary precursors and turnover products for cil
会议
  Cilia/flagella are conserved eukaryotic organelles involving in cell motility, environment sensory and embryo development.Most of ciliary proteins are trans
会议
  我们通过外显子组测序在遗传性短尾精子症中鉴定出一个与鞭毛发育相关的基因QRICH2.多组织定量PCR结果显示QRICH2基因在成体睾丸组织特异高表达.在先症者的精子鞭毛表达