Comprehensive Proteomics Coverage Reveals Multipotent Nature of Ex Vivo Expanded Adult Human Bone Ma

来源 :2008中国深圳蛋白质和多肽科学大会 | 被引量 : 0次 | 上传用户:nufjin
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  Tissue Repair Cells (TRC) are adult bone marrow mononuclear cells (BMMNC)-derived stromal stem and progenitor cells produced using single-pass perfusion technology in the AastromReplicell(R)System.Measurable and definable proteomic characterization of BMMNC and TRC may provide insights into biology and in vivo function of the cells.Using 2-D LC-MS/MS approach,643 and 869 distinct proteins were identified by multiple peptide hits with computed probability (Pcomp) > 0.95 in BMMNC and TRC respectively.These proteins represented 20 functional categories such as cell differentiating molecules,transcription factors and proteins of cell origin.
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