A G-quadruplex converts wild-type SOD1 into fibrillar aggregates under acidic conditions

来源 :第八届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：mengshenabc

【摘要】

：

Our previous studies suggest that different forms of DNA could act as an accelerating template in the wild-type Cu/Zn superoxide dismutase (wtSOD1) aggregation.

【作者】

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Xue Li Yan Meng Chanli Yang Jing Guo Dan Zhang Li Wang Changlin Liu

【机构】

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KeyLaboratoryofPesticide&ChemicalBiology,MinistryofEducation,andSchoolofChemistry,CentralChinaNormal

【出处】

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第八届全国化学生物学学术会议

【发表日期】

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2013年9期

【关键词】

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SOD1 aggregation nucleic acids G-quadruplex fibril cytotoxicity

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Our previous studies suggest that different forms of DNA could act as an accelerating template in the wild-type Cu/Zn superoxide dismutase (wtSOD1) aggregation.Here,we examined the regulation of formation and cytotoxicity of the wtSOD1 aggregates by poly(dN)12 (N =A, T, G, C) in the absence of both metal chelating and protein denaturing agents under acidic conditions.

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A G-quadruplex converts wild-type SOD1 into fibrillar aggregates under acidic conditions

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