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Ascorticalbonehasahierarchicalstructure,themacroscopicbonestrengthmaybeaffectedbythealterationsofmineralcrystalandcollagen,whicharemaincomponentsofcorticalbone.Limitedstudiesfocusedonthetimerelatedalterationsofthesetwocomponentsinosteoporosis,andtheircontributionstobonemechanicsattissuelevelandwhole-bonelevel.