免疫亲合蛋白FKBP51通过TGF-β1/Smads通路参与CCl4诱导的小鼠肝脏纤维化

来源 :第三届全国发育生物学大会 | 被引量 : 0次 | 上传用户：YAOGUOCHUN

【摘要】

：

[背景与目的]肝纤维化是各种慢性肝病向肝硬化、肝癌发展的必经阶段。虽然肝纤维化发病率高，但对其发病机制尚不完全清楚，且无有效的抗纤维化治疗手段。本研究通过创建CCl4诱导的小鼠肝脏纤维化模型，研究FKBP51在肝脏纤维化中的作用，以期研究肝脏纤维化的发生机理，并为寻找预防和治疗肝脏纤维化提供新的靶点。

【作者】

：

张玲玲徐玉雪邱彬雍伟东邓然王超

【机构】

：

中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021

【出处】

：

第三届全国发育生物学大会

【发表日期】

：

2016年8期

【关键词】

：

FKBP51 肝脏纤维化 TGF-β1/Smads信号通路

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FKBP51在抵制高脂诱导肥胖中的作用

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免疫亲合蛋白FKBP51通过TGF-β1/Smads通路参与CCl4诱导的小鼠肝脏纤维化

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