【摘 要】
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Background: Histone variant H2A.Z (Htz1 in yeast) substitution for H2A plays important roles in diverse DNA transactions.Depositing and evicting Htz1 from chromatin requires the coordination of the SW
【出 处】
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第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
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Background: Histone variant H2A.Z (Htz1 in yeast) substitution for H2A plays important roles in diverse DNA transactions.Depositing and evicting Htz1 from chromatin requires the coordination of the SWR1 remodeling complex, specific histone modifications, and histone chaperones.Histone chaperones Chz1 and Nap1 are important for the deposition Htz1 into nucleosomes.Chzl is an Htz1-H2B-specific chaperone that delivers histone Htz1 that substitutes for H2A.Nap1 can bind (H3-H4)2 tetramers, H2A-H2B dimers, and H2A.Z-H2B dimers.Spt16 functions in transcription elongation and also possesses a histone chaperone activity.However, the exact roles of these chaperones in assembling Htz1-containing nucleosome remain largely unknown.
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