Serum-Glucocorticoid Regulated Kinase 1 Inhibitor, EMD638683, Ameliorates Pulmonary Arterial Hyperte

来源 :中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户:kunan8714
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background Recruitment and altemative activation of macrophages contribute to the development of pulmonary vascular remodeling during pulmonary arterial hypertension (PAH).Serum-glucocorticoid regulated kinase 1 (SGK1) has been proved as a key regulator of macrophage inflammatory response.Its role on macrophage inflammation of PAH remains unknown.
其他文献
Background and purposes The biguanide drug Mefformin has been widely used as antidiabetic drug for treatment of hyperglycemia in patients with type 2 diabetes mellitus but has been recently shown to i
会议
Objective the role of noninvasive ventilation (NIV) in patients with acute respiratory distress syndrome (ARDS) is controversial.The objective is to investigate pathological factors that influence the
会议
Background and Aim Idiopathic pulmonary fibrosis(IPF) is a progressive,usually fatal, a special form of chronic interstitial pulmonary disease of unknown etiology and has the worst prognosis with a me
会议
Objective To evaluate the role of real-time polymerase chain reaction(PCR) of bronchoscopic biopsy specimens in the rapid diagnosis of EBTB.Methods Real-time PCR for M tuberculosis DNA in bronchial bi
会议
Objective Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway during sleep leading to intermittent hypoxia (IH).OSA may lead to liver steatosis, but the causes of the progressio
会议
Generally, chronic obstructive pulmonary disease (COPD) responds poorly to treatment with corticosteroids, with only a small proportion of patients demonstrating good outcomes based on a number of cli
会议
A 58-year-old women was diagnosed with multiple pulmonary metastasis with endobronchial spread of skin malignant melanoma.She presented with 3 months history of cough, sputum production and hemoptysis
会议
Excision repair cross-complementation group 1 (ERCC 1) protein has been associated with cisplatin resistance .The objective of this study was to investigate the correlation between the ERCC1 protein l
会议
Objective To explore diabetes concurrent pulmonary tuberculosis clinical characteristic and related case, to obtain the early diagnosis, the reasonable treatment, enhances the cure rate.
会议
BACKGROUND:Allergic diseases have been increasing in prevalence worldwide and have now become a seriouspublic health problem.In the context of public health, there currently existsinsufficient amount
会议