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Objective: the anti-angiogenic activities of Endostar on NHL cell lines and murine xenograft model of NHL in vitro and in vivo, and explored the underlying antiangiogenic mechanism of Endostar.Methods: We used MTT to study the effects of Endostar on the proliferation of EPCs, HUVECs, A20 and Raji cells in vitro, we established the models of A20 NHL xenografts in nude mice and treated the mice with Endostar, and to study the effects of Endostar on on mice NHL tumor model.Finally we analysis the expression of ERK, p-ERK, AKT and p-AKT by Western blot.