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Purpose: This study evaluated the feasibility and usefulness of computed tomography(CT)-guided iodine125(125I)brachytherapy for patients with metastatic soft tissue sarcoma(STS)after first-line chemotherapy(CT)failure.Methods: We recruited 93 patients with metastatic STS who developed progressive disease after undergoing first-line CT 4–6 times,from January 2010 to July 2015; 45 patients who had combined 125I brachytherapy and second-line CT(Group A),and 48 patients who received second-line CT only(Group B).