Epigenetic regulation of type I interferon (IFN) production in the antiviral innate immune response remains to be fully understood.
Antibodies (Abs) preferentially targeting oncogenic receptors are increasingly used for cancer therapy, but tumors often develop Ab-resistance after prolonged and costly treatment.
Induction of the transcriptional repressor Bcl-6 in CD4+ T cells is critical for the differentiation of follicular helper T cells (TFH cells), which are essential for B cell-mediated immunity.
Hepatocellular carcinomas (HCCs) are among the leading causes of global cancer-related mortality.The key regulators or signaling events underlying these malignancies remain largely unknown.
Autoimmune diseases such as multiple sclerosis (MS) and type 1 diabetes (T 1 D) are resulted from the interaction of susceptible genes and environmental factors.
Background: Regulatory B cells have gained more and more attentions in that they modulate the immune response against autoimmune diseases, infectious diseases, and tumors.
The transcriptional regulation underlying the differentiation of CD8+ effector and memory T cells remains elusive.
Background and Objective: Clinical researches have shown that many diseases such as autoimmune liver disease are often accompanied by hematopoiesis disorder.
体外循环(cardiopulmonary bypass,CPB)可通过多种因素诱发全身性炎性反应,术后大量炎症介质释放入血可损伤心、肺、脑、肾等重要脏器,易引起器官衰竭和全身炎症反应综合征(Systemic inflammatory response syndrome,SIRS).小儿心脏病患者身体各系统发育不完善,对炎性反应的耐受及调节能力差,CPB所引发的SIRS对患儿心肺等脏器的影响更为明显
目的：探讨右美托咪定(Dex)对三尖瓣下移畸形(Ebstein畸形)矫治术患者麻醉期间血流动力学、右心功能和室上性心动过速发生率的影响.方法：选择20例体外循环下行心内直视Ebstein畸形矫治术患者,随机数字表法均分为右美托咪定组(D组)和对照组(C组).D组麻醉诱导前15 min内静脉泵注0.004％Dex负荷剂量0.5 μ g/kg,诱导后吸入2％七氟醚、泵注Dex 0.7 μ g/(kg·