Invasive fungal infections have become more common in medical care in recent years.Polyene macrolides are important antifungal agents used in clinical practice with fast fungicidal effect,broad spectrum of activity and low frequency of resistance development.However, relatively high toxicity and poor water solubility limited their therapeutic efficacy.More antifungal agents are needed for treatment of fungal infections.Recently, through genome mining, a gene cluster encoding novel antifungal macrolide compounds was identified and isolated from mangrove-derived Streptomyces sp.