Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemi

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：lusx

【摘要】

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【作者】

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Lu Qian Wang Kwan Yeung Wong Chor Sang Chim

【机构】

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Department of Medicine,Queen Mary Hospital,The University of Hong Kong,Hong Kong,China

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Background A recent GWAS analysis of B-cell chronic lymphocytic leukemia (CLL) identified 12 risk loci,some of which harbor apoptosis-related tumor suppressor genes.Herein we postulate that miR-3151,localized to one GWAS-identified risk locus (8q22.3),is a tumor suppressor gene hypermethylated in CLL.

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Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemi

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