【摘 要】
:
1-Bromopropane (1-BP) is used as a substitute for ozone-depleting solvents (ODS) in industrial applications.1-BP could display central nervous system (CNS) neurotoxicity manifested by cognitive dysfun
【机 构】
:
Institute of Toxicology,School of Public Health,Shandong University,Jinan,Shandong,PR China
论文部分内容阅读
1-Bromopropane (1-BP) is used as a substitute for ozone-depleting solvents (ODS) in industrial applications.1-BP could display central nervous system (CNS) neurotoxicity manifested by cognitive dysfunction.Neuroglobin (Ngb) is an endogenous neuroprotectant and is predominantly expressed in the nervous system.The present study aimed to investigate Ngb involvement in CNS neurotoxicity induced by 1-BP in rats.
其他文献
Recently,amorphous silicon nanoparticles (SNPs) are widely used in a variety of fields,especially in biological and medical science.Thus,the adverse effect of these nanoparticles should be carefully i
Objectives:Using the separation and enrichment characteristics of magnetic nanoparticles and unique fluorescence properties of quantum dots,we build a simple quick,high sensitivity and specificity to
目的:顺铂(cDDP)作为细胞周期非特异性抗肿瘤药应用于一线抗肝癌(HCC)的高效化疗;有研究表明cDDP可导致HCC细胞周期阻滞而抑制增殖;而且人群中肝癌对cDDP治疗的敏感性不同。蛋白磷酸酶2A(PP2A)通过对信号通路分子的去磷酸化作用,参与调控细胞增殖、细胞周期、DNA损伤修复等过程;其中B55δ亚基由PPP2R2D基因编码,我们前期研究验证该基因3,UTR+ 15 G>C多态性位点受mi
目的 纳米科技的高速发展伴随着纳米材料的安全性日益受到人们的重视。与大尺寸材料相比,纳米材料本身具有很多独特的性质,这些性质与纳米材料所致生物学效应之间有着直接的联系。为了应对纳米新材料的大量出现,纳米毒理学领域需要高通量与高灵敏的毒理学筛选评价方法进行纳米材料的安全性评价。
Despite the widespread application of silica nanopartieles (SiNPs) in industrial,commercial,and biomedical fields,their response to human cells has not been fully elucidated.Overall,little is known ab
目的 随着纳米SiO2在人类生产生活中越来越广泛的应用,其诱导的细胞毒性及机制已经成为近年来的研究热点,目前已有大量文献报道纳米SiO2的细胞毒性与引发胞内活性氧自由基ROS (reactive oxygen species)水平升高密切相关,但其作用机制并不明确.TRPM2 (Transient potential receptor melastatin-2)是一种氧化应激损伤激活的非选择性阳离
目的 1,3-丁二烯(1,3-Butadiene,BD)是一种重要的化工原料,可导致职业人群的健康损害.由于BD也在汽车尾气、香烟烟雾及食用油烟中普遍存在,因而被认定为居民住宅环境区的主要污染物之一.国际癌症研究组织(IARC)已于2008年将其确认为人类致癌物(Ⅰ类).BD的活性中间代谢产物1,2,3,4-二环氧丁烷(1,2,3,4-diepoxybutane,DEB)具有较强的遗传毒性,可诱导
Objective:To explore the correlation between the change of the activeity of succinate dehydrogenase(SDH) and cell cycles in SH-SY5Y cells exposed to Manganese(Mn2+).Methods:SH-SY5Y cells are divided i
目的 为蛹虫草安全性研究提供毒理学依据,进而对其开发利用提供安全性参考.方法 按照卫生部《保健食品检验与评价技术规范》(2003版)对江苏某企业送检的蛹虫草样品进行(1)大鼠急性经口毒性试验,一次最大限量法.采用SPF级SD大鼠,体重为180-220 g,共20只,雌雄各半,剂量设计为10000mg/kg b.wt..大鼠禁食过夜后分两次灌胃给予,中间间隔4h,灌胃容量均为10ml/kg b.wt
Background:1-Bromopropane (1-BP) is an alternative to ozone depleting solvent that widely used in industrial production.Occupational exposure to 1-BP is an issue of concern since 1-BP has neurotoxicit