PEGylated dendritic diaminocyclohexyl-platinum (Ⅱ) conjugates as pH-responsive drug delivery vehicle

来源 :中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：dmf625

【摘要】

：

【作者】

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Dayi Pan Wenchuan she Chunhua Guo Kui Luo Qiangying Yi Zhongwei Gu

【机构】

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National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China

【出处】

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中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议

【发表日期】

：

2014年6期

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Environmentally-responsive peptide dendrimers loaded with drugs are suitable candidates for cancer therapy.In this study,we report the preparation and characterization of mPEGylated peptide dendrimer-linked diaminocyclohexyl platinum (Ⅱ) (dendrimer-DACHPt) conjugates as pH-responsive drug delivery vehicles for tumor suppression in mice.The DACHPt is similar to oxaliplatin and was linked to dendrimer via N,O-coordination;azido mPEG chains were conjugated to the dendrimers via a Cu(Ⅰ) catalyzed alkyne-azide click cycloaddition (CuAAC).

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PEGylated dendritic diaminocyclohexyl-platinum (Ⅱ) conjugates as pH-responsive drug delivery vehicle

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