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Objective: To investigate the correlation between glutathione S-transferase P 1 (glutathione S-transferase P 1, GSTP 1) gene A105G and ribonucleotide reductase subunit 1 (ribonucleotide reductase, RRM1) C37A-T524C gene polymorphisms and the chemotherapy sensitivity and toxicity of gemcitabine combined cisplatin (GP) programs for non-small celllung cancer (NSCLC).