Cell surface receptors play a critical role in modulating intracellular signal transduction,making them important drug targets.However,it remains challenging to develop a selective and efficient strat
The success of chemotherapy is often limited because of the development of drug resistance.Emerging evidence has shown that chemoresistance associates with acquisition of epithelial-mesenchymal transi
Precise perturbation of protein function with high selectivity and temporal resolution,especially in the gain-of-function manner,is crucial to dissect various dynamic biological processes.Although the