Nuclear receptor FXR:a critical transcription factor in regulating collecting duct water reabsortion

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：cxxuxu

【摘要】

：

【作者】

：

Xiao-yan Zhang Shi-zheng Huang Yuan-yi Wei Bing Wang You-fei Guan

【机构】

：

Advanced Institute for Medical Sciences,Dalian Medical University,Dalian,Liaoning 116044,China;Astra

【出处】

：

2016年国际生理学学术大会

【发表日期】

：

2016年6期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The farnesoid X receptor(FXR)is a ligand-activated transcription factor belonging to the nuclear receptor superfamily.FXR is mainly expressed in liver and small intestine,where it plays an important role in bile acid,lipid,and glucose metabolism.The kidney also has a high FXR expression level,with its physiological function largely unknown.

其他文献

EGCG Inhibits Hepatocellular Careinoma Progression via promoting cell apoptosis and inhibiting cell

Hepatocellular carcinoma(HCC)is one of the most mortal disease,the metastasis and recurrence are the most important factors that affect the therapy of HCC chronically.

会议

无针注射进行瘢痕内药物注射疗效及其影响因素分析

会议

Different Ways of Training on Respiratory Metabolism of Fructose Preference Rats

Objective: food addiction is relevant to homeostasis and neuronal adaptation,causing nerve special adaptation.Food can activate the reward mechanism in the brain,its disorder may lead to the increased

会议

ITGB4 knoukout promotes airway hyper-responsiveness and Th2 inflammation responses in HDM-stressed m

Airway epithelial cells have been postulated to play an important role in the parthenogenesis of asthma.Although the structural and functional defects of airway epithelial cells have been speculated t

会议

integrin β4airway epithelial cellsallergyinflammationasthma

Influence of estrogen receptor α phosphorylation at serine 309 on male reproductive function of mice

Recent studies in estrogen receptor α(ERα)knockout mice have demonstrated that the testicle development is abnormal,and that sperm recovered from cauda epididymis exhibit reduced motilities and fail t

会议

ERαphosphorylationknock-inmale reproduction

Effect of muscarinic acetylcholine receptor activation on paracellular pathway in submandibular glan

Paracellular pathway via tight junction is an important route for materials transport.However,whether muscarinic acetylcholine receptors(mAChRs)regulate tight junction proteins of submandibular gland,

会议

tight junctionmuscarinic acetylcholine receptorsubmandibular glandclaudin-4

Novel hEAG channel inhibitors from spider venoms

Kv10.1(hEAG)is a member of the large family of voltage-gated potassium channels.Functional channels are homotetramers,with each monomer comprised of six transmembrane segments.hEAG channels are distin

会议

Hepatocellular injury after noise exposure mediated by Acid sphingomyelinase/Ceramide pathway

Introduction: Chronic exposure to noise might induce liver damage including increased oxidative stress in hepatocyte,liver tissue loose and edema,vascular congestion and inflammatory cell infiltration

会议

NoiseHepatocyteAcid sphingomyelinaseCeramide

Ghrelin Ameliorates NAFLD Induced by Low grade Inflammation

Ghrelin,a 28-amino acid hormone produced mainly by theX/A-like endocrine cells in gastric mucosa,is critical for the regulation of energy metabolismand inflammation.It is currently unknown whether ghr

会议

GhrelinLPSKupffer cellsNAFLD

NSun2 deficiency ameliorates hyperhomocysteinemia-induced IL-17A secretion via suppressing mRNA meth

Hyperhomocysteinemia(HHcy)is an independent risk factor for atherosclerosis with high secretion of interleukin-17A(IL-17A)in T lymphocytes.However,the mechanisms underlying the regulation of IL-17A ar

会议

Inteleukin-17NSun2MethylationT cell

Nuclear receptor FXR:a critical transcription factor in regulating collecting duct water reabsortion

与本文相关的学术论文