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5. DEPRESSION OF P53-INDEPENDENT AKT-SURVIVAL SIGNALS IN HUMAN ORAL CANCER CELLS AFTER EXPOSURE TO HIGH

DEPRESSION OF P53-INDEPENDENT AKT-SURVIVAL SIGNALS IN HUMAN ORAL CANCER CELLS AFTER EXPOSURE TO HIGH

来源 :第三届亚洲辐射研究大会 | 被引量 : 0次 | 上传用户：jcd041991

【摘 要】

：

Although mutations and deletions of the p53 tumor suppressor gene lead to resistance to low linear energy transfer (LET) radiation, high LET radiation efficiently induces cell lethality and apoptosis

【作 者】

：

Yosuke Nakagawa Akihisa Takahashi Yoshiya Furusawa Tadaaki Kirita Takeo Ohnishi 

【机 构】

：

Nara Med.Univ.,840 Shijo-cho,Kashihara,Nara 634-8521,Japan

【出 处】

：

第三届亚洲辐射研究大会

【发表日期】

：

2013年2期

【关键词】

：

high LET Akt mTOR apoptosis cell cycle 

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论文部分内容阅读

Although mutations and deletions of the p53 tumor suppressor gene lead to resistance to low linear energy transfer (LET) radiation, high LET radiation efficiently induces cell lethality and apoptosis regardless of p53 gene status in cancer cells.

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