SNX10 belongs to the sorting nexin (SNX) family, which contains the PX domain and involved in protein trafficking.SNX10 does not have other reported domain except the PX domain, which is a phosphoinositides (Pls) binding domain.Previous reports suggested that SNX 10 is localized to the Rab5 positive organelles, and the overexpression of SNX10 induces the formation of giant vacuoles in mammalian cells.Since most giant vacuoles induced by SNX 10 overexpression are Rab7 positive, SNX10 might promote late endosome maturation.