【摘 要】
：
The LRP8 gene encodes the low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2).LRP8 is a cell surface r
【机 构】
：
HuazhongUniversityofScience&Technology
【出 处】
：
2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
The LRP8 gene encodes the low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2).LRP8 is a cell surface receptor that belongs to the low-density lipoprotein receptor family.Our previous genome-wide linkage scan of 428 nuclear families identified a significant genetic susceptibility locus for premature myocardial infarction (MI) on chromosome 1 p34-36.Follow-up association studies identified a functional genomic variant, R952Q in the LRP8 gene, that was associated with increased platelet activation and familial and early-onset coronary artery disease (CAD) and MI.
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