A novel Ensemble Decision Tree Approach to Mining Genes Coding ion Channels for Cardiopathy Subtype

来源 :2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会) | 被引量 : 0次 | 上传用户:weihome
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Ion channels are critical for the normal physiological function of the organism.The functional abnormality of the ion channels may cause many disorders named channelopathy.Meanwhile,ion channels are one of the few proteins that can be efficiently regulated by small molecule drugs,so they are ideal candidates for drug targets.As we know,there are few reports on the application of pattern recognition method that is used for analyzing the dataset of the gene expression profile related to ion channels and transmembrane proteins at present.Upon these viewpoints,it is known that research on ion channels will bring great scientific and practical value.Here,we proposed a novel ensemble decision tree approach,which is based on mining genes that are encoding the ion channels and transmembrane proteins.
其他文献
Human β-amyloid (1-42) peptide is a major component of the plaque deposits found in the brains of Alzheimers disease patients.Synthesis of the β-amyloid (1-42) peptide by conventional solid phase pept
会议
Currently fetal DNA in maternal plasma cannot be used for the reliable analysis of fetal alleles involving point mutations.We have recently shown that a selective enrichment of fetal DNA sequences can
会议
In genetic isolated populations,a far higher prevalence of certain genetic disorders can be observed which mainly due to founder effects.The mutant alleles in those genetic disorders usually show high
会议
Microarray technology,widely used for gene expression profiling,can be used to investigate the cellular role of all genes,identify new drug targets and discover new methods to characterize and treat c
会议
Thymidylate synthase (TS),is a critical target for cancer chemotherapy and is one of the most extensively studied predictive biomarkers for fluoropyrimidine-based chemotherapy.In addition to its criti
会议
Lichens are found in terrestrial biomes worldwide.They are dual organisms composed ofa fungal and a photosynthetic partner.Lichens characteristically grow in low nutrient environments such as on rocks
会议
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease caused by the production of pathogenic autoantibodies to a spectrum of ubiquitous nuclear and cytoplasmic antigens.These autoantib
会议
Various mammalian species have been used for research on somatic cell nuclear transfer (SCNT).The bovine oocyte is an excellent model for establishing comparable biological parameters for SCNT.The aim
会议
1 Institute of Biology,Leiden University,2 Microbial Physiology Research Group,University of Groningen,Kerklaan 30,9751 NN,Haren,The Netherlands,3 Section Fungal Genomics,Wageningen University,Dreijen
会议
In this study,a proto-oncogene and suppressor-tumor gene DNA microarray was utilized to analyze gene expression patterns in one primary cervical carcinoma.Total 11 genes (3.4%) showing consistently up