【摘 要】
：
BMX(also termed ETK) kinase is a member of the TEC family non-receptor tyrosine kinases(which also include ITK,TEC,BTK and TXK),and is the major member expressed in epithelial cells including prostate
【机 构】
：
High Magnetic Field Laboratory,Chinese Academy of Sciences,Hefei,Anhui,230031;Dana Farber Cancer Ins
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
BMX(also termed ETK) kinase is a member of the TEC family non-receptor tyrosine kinases(which also include ITK,TEC,BTK and TXK),and is the major member expressed in epithelial cells including prostate epithelium.(1,2)Accumulated evidence showed that BMX deregulation is associated with prostate cancer.(3) However,currently there is no selective and potent BMX inhibitor available to help dissect the detailed pathology.Through a structure based drug design approach,we have developed a highly selective and potent irreversible inhibitor QL-Ⅻ-61 which target the cysteine residue in the BMX ATP binding domain.
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