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Three new saponins(1-3)and a new natural product(4)together with six known compounds were isolated from the whole plant of Reineckia carnea.Their structures were determined by detailed analysis of their 1D and 2D NMR spectra,MS and comparison with literatures.In addition,all the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide(NO)production in RAW 264.7 macrophages.Compounds 1-4 inhibited LPS stimulated NO production in RAW 264.7 macrophages with IC50 values of 37.5 μM,31.4 μM,34.6 μM,56.1 μM,respectively.Compounds 5-10 showed inhibitory activities with IC50 values ranging from 20.3 to 42.9 μM.